Detection the Associated Factors and Medications Used in Renal Transplantation of Osteoporosis Patients

Abstract

Background: Osteoporosis is considered one of the complications that occur post renal transplantation. The pathophysiology of underlying bone disorders after renal transplantation results from a variety of causes, such as immunosuppression drugs and alterations in the parathyroid hormone level, vitamin D level as well as changes in mineral metabolism.

Aim of study: to detect the associated factors and medications used in renal transplantation of Osteoporosis in a sample of Iraqi patients.

Patients and Methods: A cross sectional study conducted in Baghdad Renal Transplant Center in Iraq, over a period of 12 months from Jan-2017 to Dec-2017 on 90 candidate (67 males and 23 females). A Questionnaire used to collect data, history was taken, thorough examination was done including height and weight to estimate BMI, all participants were sent for serum creatinine, serum calcium, serum phosphorus, parathyroid hormone, vitamin D.

Results: Mean age of study patients was 37.48 ± 12.96 years; 74.4% were males and 77.8% were married. 51.1% of them had normal body mass index and 71.1% lived in urban areas. The cause of renal transplant was unknown in 72.2% of cases and 93.3% of the patients did renal transplant once. Serum Calcium was normal in 70% of them. Osteoporosis was seen in 47.8% of cases. Diabetes mellitus, causes of renal failure and number of renal transplant, Vitamin D deficiency were considered as significantly associated with osteoporosis after renal transplantation.

Conclusions: There is a high prevalence of osteoporosis among Iraqi patients after renal transplantation. And they included several complications such as renal failure, number of renal transplantation and vitamin D deficiency were significant risk factors that associated with osteoporosis after renal transplantation.