Effect of Medical Therapy on The Osteoprotegerin Levels in Patients with Hypothyroidism


  • Hanan Omar Khorsheed College of Medicine, Tikrit University, Tikrit, Iraq
  • Entedhar R. Sarhat College of Dentistry, Tikrit University, Tikrit, Iraq


Osteoprotegerin, hypothyroidism, Thyroid hormones, medical therapy


Hypothyroidism is a clinical condition that needs primary care. It is increased with age and is more prevalent in females. Biochemical testing is used to identify hypothyroidism. Overt primary hypothyroidism is characterized by blood levels of thyroid-stimulating hormone (TSH) that are higher than normal and thyroxine levels that are lower than normal. The purpose of this research was to measure osteoprotegerin in hypothyroid individuals and look into how levothyroxine affected these patients' osteoprotegerin levels. For this purpose, 180 subjects (40 control groups and 70 patients with hypothyroidism underwent treatment, for 3 months) were selected for the study. The study materials were registered from the laboratories in Kirkuk city. The results are summarized in the following points: Osteoprotegerin Levels was highly significantly increased (0.0192) in hypothyroid patients compared to the control group, according to before and after treatment. Serum Level of Human TPO (Thyroid Peroxidase) in Women was significantly difference (0.0001significant) in hypothyroid patients compared to the control group, according to before and after treatment. The parameters of Thyroid hormones TSH, T3 and T4 were highly significantly increased (P < 0.001) in the serum of hypothyroid patients compared to the control group, according to before and after treatment. Osteoprotegerin was elevated significantly in hypothyroidism patients, it may be involved in the pathophysiology of hypothyroidism.


W. K. Balwan and S. Kour, “Thyroid Health & Methylation: What is the Link,” Scholars Journal of Applied Medical …, 2022, [Online]. Available: https://www.researchgate.net/profile/Wahied-Balwan-2/publication/366672693_Thyroid_Health_Methylation_What_is_the_Link/links/63adcef8a03100368a39c185/Thyroid-Health-Methylation-What-is-the-Link.pdf

E. R. Sarhata, M. M. Al Anzyb, and ..., “Study of oxidant-antioxidant status in cerebrospinal fluid of children with meningitis,” Eurasian Chem Commun, 2022, [Online]. Available: https://www.researchgate.net/profile/Entedhar-Sarhat/publication/361074215_Study_of_oxidant-antioxidant_status_in_cerebrospinal_fluid_of_children_with_meningitis/links/629a8afca3fe3e3df85af478/Study-of-oxidant-antioxidant-status-in-cerebrospinal-fluid-of-children-with-meningitis.pdf

A. G. Unnikrishnan, S. Kalra, R. K. Sahay, and ..., “Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India,” Indian journal of …, 2013, [Online]. Available: https://journals.lww.com/indjem/fulltext/2013/17040/Prevalence_of_hypothyroidism_in_adults__An.14.aspx

S. Allow and E. Sarhat, “METFORMIN EFFECTS ON BLOOD LEVELS OF GREMLIN-1 IN POLYCYSTIC OVARIAN WOMEN.,” Georgian Med News, 2023, [Online]. Available: https://europepmc.org/article/med/37354673

J. Jonklaas, A. C. Bianco, A. R. Cappola, and ..., “Evidence-based use of levothyroxine/liothyronine combinations in treating hypothyroidism: a consensus document,” European thyroid …, 2021, [Online]. Available: https://etj.bioscientifica.com/view/journals/etj/10/1/ETJ512970.xml

E. R. Sarhat, S. A. Wadi, and ..., “Effect of ethanolic extraction of moringa oleifera on paraoxonase and arylesterase enzyme activity in high fat diet-induced obesity in rats,” Research Journal of …, 2018, [Online]. Available: https://www.indianjournals.com/ijor.aspx?target=ijor:rjpt&volume=11&issue=10&article=072

A. R. Tantri and S. Syafril, “Pre-Procedure Intervention of Subclinical Hypothyroidism: Case Report,” Journal of Endocrinology, Tropical Medicine …, 2022, [Online]. Available: https://talenta.usu.ac.id/jetromi/article/view/12701

A. Bikas and K. D. Burman, “The Thyroid and Its Diseases: A Comprehensive Guide for the Clinician.” 2019.

M. Tawfeq and E. Sarhat, “METFORMIN EFFECTS ON NEUREGULIN-1 IN POLYCYSTIC OVARIAN WOMEN.,” Georgian Med News, 2023, [Online]. Available: https://europepmc.org/article/med/37354674

D. Monir, A. Osama, A. E. Saad, M. Negm, and ..., “Role of osteoprotegerin rs3102735 gene polymorphism in acute ischemic stroke patients,” The Egyptian Journal of …, 2023, doi: 10.1186/s41983-023-00652-4.

S. H. Hooshiar, M. Tobeiha, and S. Jafarnejad, “Soy isoflavones and bone health: Focus on the RANKL/RANK/OPG pathway,” BioMed Research …, 2022, [Online]. Available: https://www.hindawi.com/journals/bmri/2022/8862278/

G. G. Hussien and O. H. Ali, “Evaluation of Salivary Osteoprotegerin in Hypothyroidism and Periodontitis Patients Case-Control Study,” Egypt J Hosp Med, 2023, [Online]. Available: https://journals.ekb.eg/article_293475.html

J. Xie et al., “99Tc-Methylene Diphosphonate Treatment is Safe and Efficacious for Osteoporosis in Postmenopausal Differentiated Thyroid Cancer Patients Undergoing TSH …,” Cancer Management …, 2023, doi: 10.2147/CMAR.S354471.

S. Khamisi, F. A. Karlsson, Ö. Ljunggren, M. Thulin, and ..., “Increased plasma levels of soluble programmed death ligand 1 (sPD-L1) and fibroblast growth factor 23 (FGF-23) in patients with Graves’ ophthalmopathy in …,” Cytokine, 2023, [Online]. Available: https://www.sciencedirect.com/science/article/pii/S1043466623001473

A. Lamichhane, P. Bista, S. Pokhrel, K. Bolakhe, and ..., “Assessment of Cardiovascular Disease Risk in Females with Subclinical Hypothyroidism,” J Lipids, 2023, [Online]. Available: https://www.hindawi.com/journals/jl/2023/4440275/

X. Guang-da, S. Hui-ling, C. Zhi-song, and ..., “Changes in plasma concentrations of osteoprotegerin before and after levothyroxine replacement therapy in hypothyroid patients,” The Journal of Clinical …, 2005, [Online]. Available: https://academic.oup.com/jcem/article-abstract/90/10/5765/2839512

A. P. Delitala, A. Scuteri, and C. Doria, “Thyroid hormone diseases and osteoporosis,” J Clin Med, 2020, [Online]. Available: https://www.mdpi.com/2077-0383/9/4/1034

M. S. Hamad, E. R. Sarhat, S. J. Khalaf, T. R. Sarhat, and ..., “Characteristic Abnormalities In Serum Biochemistry In Patients With Breast Cancer,” Syst Rev …, 2020, [Online]. Available: https://www.academia.edu/download/66087586/Breast_cancer.pdf

A. E. Büchi, M. Feller, S. Netzer, M. R. Blum, E. G. Rodriguez, and ..., “Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: A nested study within a randomized placebo controlled trial,” Bone, 2022, [Online]. Available: https://www.sciencedirect.com/science/article/pii/S8756328222000801

S. N. Jayash, N. M. Al-Namnam, and ..., “Osteoprotegerin (OPG) pathways in bone diseases and its application in therapeutic perspectives,” … Research in Applied …, 2021, [Online]. Available: https://biointerfaceresearch.com/wp-content/uploads/2020/02/20695837102193200.pdf

I. J. Mohammed, E. R. Sarhat, M. A. S. Hamied, and T. R. Sarhat, “Assessment of salivary interleukin (IL)-6, IL-10, oxidative stress, antioxidant status, pH, and flow rate in dental caries experience patients in Tikrit Province,” Sys Rev Pharm, 2021, [Online]. Available: https://www.academia.edu/download/65235751/il6_caries.pdf

I. M. Abid, S. J. Khalaf, S. A. Zbaar, and ..., “Dental caries and hormonal changes in postmenopausal women.,” … de Farmacologia y …, 2022, [Online]. Available: https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=07980264&AN=159776263&h=2mmu%2BXAOTXrEsWbtd6s4g%2BSg3iYr1qS3dpUW%2BJ9rkWDSY3zVsc31yU6VJPn90L%2FaRWMU8oE%2BWsO2irCpMMgjLw%3D%3D&crl=c

K. Sarhat and T. H. Jabir, “Assessment of melatonin and oxidant-antioxidant markers in infertile men in Thi-Qar Province,” Indian J. Forensic Med. Toxicol, 2019, [Online]. Available: https://www.researchgate.net/profile/Entedhar-Sarhat/publication/336968650_Assessment_of_melatonin_and_oxidant-antioxidant_markers_in_infertile_men_in_Thi-Qar_Province/links/5ef2652e92851cba7a42b5a4/Assessment-of-melatonin-and-oxidant-antioxidant-markers-in-infertile-men-in-Thi-Qar-Province.pdf

R. Negro, T. Mangieri, L. Coppola, G. Presicce, and ..., “Levothyroxine treatment in thyroid peroxidase antibody-positive women undergoing assisted reproduction technologies: a prospective study,” Human …, 2005, [Online]. Available: https://academic.oup.com/humrep/article-abstract/20/6/1529/748928

Y. Shimizu, S. Y. Kawashiri, Y. Noguchi, Y. Nagata, and ..., “Normal range of anti–thyroid peroxidase antibody (TPO-Ab) and atherosclerosis among eu-thyroid population: a cross-sectional study,” Medicine, 2020, [Online]. Available: https://journals.lww.com/md-journal/fulltext/2020/09180/normal_range_of_anti_thyroid_peroxidase_antibody.54.aspx

B. J. Wells and W. J. Hueston, “Are thyroid peroxidase antibodies associated with cardiovascular disease risk in patients with subclinical hypothyroidism?,” Clin Endocrinol (Oxf), 2005, doi: 10.1111/j.1365-2265.2005.02262.x.

A. Kachouei, H. Rezvanian, M. Amini, and ..., “The effect of levothyroxine and selenium versus levothyroxine alone on reducing the level of anti-thyroid peroxidase antibody in autoimmune hypothyroid …,” Advanced Biomedical …, 2018, [Online]. Available: https://journals.lww.com/adbm/_layouts/15/oaks.journals/downloadpdf.aspx?an=01679891-201807000-00001

E. J. van Zuuren, A. Y. Albusta, and ..., “Selenium supplementation for Hashimoto’s thyroiditis,” Cochrane Database …, 2013, doi: 10.1002/14651858.CD010223.pub2.

R. Negro, G. Greco, T. Mangieri, and ..., “The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies,” The Journal of …, 2007, [Online]. Available: https://academic.oup.com/jcem/article-abstract/92/4/1263/2596911

H. Onal, G. Keskindemirci, E. Adal, A. Ersen, and ..., “Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study,” Journal of Pediatric …, 2012, doi: 10.1515/jpem-2012-0078.

A. D. Anastasilakis, K. A. Toulis, and ..., “Selenomethionine treatment in patients with autoimmune thyroiditis: a prospective, quasi‐randomised trial,” … journal of clinical …, 2012, doi: 10.1111/j.1742-1241.2011.02879.x.

G. P. S. Shantha, A. A. Kumar, V. Jeyachandran, and ..., “Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross–sectional study from South India,” Thyroid Res, 2009, doi: 10.1186/1756-6614-2-2.

M. H. Stipanuk, Biochemical and Physiological Aspects of Human Nutrition. Pennsylvania. Philadelphia: WB Saunders …, 2000.

N. Y. Choksi, G. D. Jahnke, C. St. Hilaire, and ..., “Role of thyroid hormones in human and laboratory animal reproductive health,” Birth defects research …, 2003, doi: 10.1002/bdrb.10045.

M. Rotondi, P. Leporati, A. La Manna, and ..., “Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism?,” European journal of …, 2009, [Online]. Available: https://academic.oup.com/ejendo/article-abstract/160/3/403/6676337

N. Knudsen, P. Laurberg, L. B. Rasmussen, and ..., “Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population,” The Journal of …, 2005, [Online]. Available: https://academic.oup.com/jcem/article-abstract/90/7/4019/2837271

M. Bastemir, F. Akin, E. Alkis, and B. Kaptanoglu, “Obesity is associated with increased serum TSH level, independent of thyroid function,” Swiss Med Wkly, 2007, [Online]. Available: https://www.smw.ch/index.php/smw/article/download/758/755

S. U. Sawant, S. Chandran, A. F. Almeida, and ..., “Correlation between oxidative stress and thyroid function in patients with nephrotic syndrome,” International journal of …, 2011, [Online]. Available: https://www.hindawi.com/journals/ijn/2011/256420/abs/

L. C. Fontenelle, M. M. Feitosa, J. S. Severo, and ..., “Thyroid function in human obesity: underlying mechanisms,” Hormone and …, 2016, doi: 10.1055/s-0042-121421.

J. G. Hollowell, N. W. Staehling, and ..., “Serum TSH, T4, and Thyroid Antibodies in the United States Population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III),” The Journal of …, 2002, [Online]. Available: https://academic.oup.com/jcem/article-abstract/87/2/489/2846568

T. Vadiveloo, P. T. Donnan, M. J. Murphy, and ..., “Age-and gender-specific TSH reference intervals in people with no obvious thyroid disease in Tayside, Scotland: the Thyroid Epidemiology, Audit, and Research …,” The Journal of Clinical …, 2013, [Online]. Available: https://academic.oup.com/jcem/article-abstract/98/3/1147/2536719

R. Mansoor, S. S. R. Rizvi, W. Kausar, F. Aslam, and ..., “Comparison of TSH, T4 and T3 levels in primary hypothyroidism in relation to gender and age in a tertiary care hospital,” Ann. Pak. Inst. Med …, 2011, [Online]. Available: https://www.apims.net/apims_old/Volumes/Vol7-4/COMPARISON%20OF%20TSH_T4%20AND%20T3%20LEVELS%20IN%20%20PRIMARY%20HYPOTHYROIDISM%20IN%20RELATION%20TO%20GENDER%20AND%20AGE%20_%20%20A%20CROSS-SECTIONAL%20STUDY%20IN%20A%20TERIARY%20CARE%20HOSPITAL.pdf

A. J. Dhok, P. S. Adole, P. V Puppalwar, and ..., “Status of Thyroid disorders at Acharya Vinobha Bhave Rural Hospital, Sawangi (Meghe), Wardha, India,” Thyroid Research and …, 2015, [Online]. Available: https://journals.lww.com/trap/fulltext/2015/12020/status_of_thyroid_disorders_at_acharya_vinobha.5.aspx

R. Negro and J. H. Mestman, “Thyroid disease in pregnancy,” Best practice &research Clinical endocrinology & …, 2011, [Online]. Available: https://www.sciencedirect.com/science/article/pii/S1521690X11000868

R. Rajput, V. Goel, S. Nanda, M. Rajput, and ..., “Prevalence of thyroid dysfunction among women during the first trimester of pregnancy at a tertiary care hospital in Haryana,” Indian journal of …, 2015, [Online]. Available: https://journals.lww.com/indjem/fulltext/2015/19030/prevalence_of_thyroid_dysfunction_among_women.19.aspx

K. Mahadik, P. Choudhary, and P. K. Roy, “Study of thyroid function in pregnancy, its feto-maternal outcome; a prospective observational study,” BMC Pregnancy Childbirth, 2020, doi: 10.1186/s12884-020-03448-z.




How to Cite

Khorsheed, H. O. ., & Sarhat, E. R. (2024). Effect of Medical Therapy on The Osteoprotegerin Levels in Patients with Hypothyroidism. World of Science: Journal on Modern Research Methodologies, 3(2), 39–48. Retrieved from https://univerpubl.com/index.php/woscience/article/view/3197