Study Some Biochemical Parameters nd Interleukin-6 (+174C/G) Gene Polymorphism In Patients With Hepatitis B

Abstract

The current study was aimed to estimate interleukin-10 concentrations with studying the IL-6 (+174 C/G) gene polymorphism in an individual with Hepatitis B. This study involved 100 with hepatitis B individual. A total of (60) patients with hepatitis B were included in this investigation. The patients were between the ages of 15 and 60. These patients were hospitalized to Kirkuk, Iraq's Al-Jumhuri Hospital between January and March 2022. (2022). 30 healthy individuals served as the control group in this experiment. As compared to the control group, hepatitis B patients' liver enzyme (AST & ALT) and interleukin (4 & 6) activity significantly increased (P≤0.05). For molecular study, the findings exhibited that genotype (CG) had the highest frequency of 25 (41.7%) in hepatitis B individuals versus a lower frequency through normal individuals group 6 (20%), whereas genotype (CC) had the frequency of 24 (40%) in hepatitis B individuals compared to the highest frequency of 20 (66.7%) in normal individuals group. The genotype (GG) was found in 11 (18.3%) hepatitis B individuals compared to 4 (13.3%) in normal individuals group. Therefore, its concluded that the IL-6 (+174 C/G) gene was found to be related with hepatitis B risk in the Iraqi population.