Evaluation CD4 T Lymphocyte in Rheumatoid Arthritis Patients in Karbala Province

Abstract

Introduction: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized clinically by inflammatory arthritis and extra-articular involvement. CD4+ T cells form a large proportion of the inflammatory cells invading the synovial tissue, and are involved in the RA pathologic process

Methodology: A total of 50 RA patients and 50 healthy control subjects were included. All subjects did not have other autoimmune disease except RA, tumor, active infection, or a history of related drug administration. Peripheral blood mononuclear cells were isolated and analyzed by flow cytometry .

Results: Our analyses revealed CD4 T-Cell were positive correlated with erythrocyte sedimentation rate and C-reactive protein levels in RA patients.

Conclusions: Our results indicate that CD4-T cells play an important role in modulating RA disease activity and can serve as a parameter of disease activity.