Activity of the Pro and Antioxidant System in Erythrocyte Membranes in Children with Primary and Recurrent Laryngotracheitis

Abstract

The main importance in the pathogenesis of functional disorders of organs and systems in acute constrictive laryngotracheitis in children is respiratory insufficiency, manifested by a violation of external, pulmonary and tissue respiration, hypoxia and hypoxemia. Under the influence of hypoxia and hypercapnia, the functional state of the central nervous system and the neuro-reflex regulation of the vital activity of the body are disrupted. Metabolic changes occur as a result of dysfunction of the most important organs and systems in the body. Violation of gas exchange and redox processes, hypoxia and hypoxemia lead to activation of anaerobic oxidation of under–oxidized metabolic products. Under the influence of hypoxia, bacterial toxins, products of impaired metabolism and changes in hemodynamics in children with acute stenosing laryngotracheitis, violations of the function of vital organs are noted. These changes are accompanied by an increase in the activity of LPO processes and the restructuring of the antioxidant protection systems of red blood cells.