Morphological Features of Laryngeal Cancer Diagnosis

Abstract

Immunohistochemistry in laryngeal cancer taLCets predictive factors of PCNA, p53, Ki67 that correlate with histopathological degree of lesion and development. Our study highlights the need and importance of a multidisciplinary approach to laryngeal malignancies, focusing on the comparison of clinical and morphological information with histological and immunohistochemical analysis of tumor protein p53, nuclear proliferation antigens PCNA and Ki-67 and epidermal growth factor receptor and CD44 antigen is increased expression of EGFR, which is associated with late stage, poor survival and resistance to treatment (radiation therapy).