State of the Peripheral Blood System in Patients with Rheumatoid Arthritis Depending on Haptoglobin Polymorphism

Abstract

The role of haptoglobin in the body is not limited to the function of hemoglobin transport. Literature data indicate that the exchange of Hb is closely related to processes occurring in connective tissue. According to our data, Hp 2-2 plays a role in the development of chronic inflammatory reaction (92.6%), the Hp 1-1 type is favorable, and 2-1 is characterized by a rapid course in 55.6% of patients. The aim of our further research was to study laboratory data in RA patients with different haptoglobin phenotypes. As is known, in recent years, the degree of anemia is considered a prognostic indicator of RA and is included in the criteria determining the activity of the disease. According to the literature, the greater the degree of anemia, the worse the prognosis of the disease. In our studies, the average hemoglobin content in the peripheral blood of RA patients was 79.1±1.7 g/L, and the erythrocyte count was 2.8±0.06x10¹²/L, reflecting a moderate degree of anemia. Changes in hemoglobin content and erythrocyte count with different haptoglobin phenotypes are shown in Table 3.5.