The Clinicopathological Features of Malignant Lymphoma Cases in Adiwaniyah Province in Iraq
Keywords:
Non-Hodgkin lymphoma, immunohistochemical, IraqAbstract
Keywords
Non-Hodgkin lymphoma, immunohistochemical, Iraq
Received: April 25, 2023
Accepted: May 23, 2023
Published: June 24, 2023
Article Information
Background: In general, lymphoma is grouped into two major classes, Hodgkin lymphoma and Non-Hodgkin lymphoma, approximately 10 % and 90 %, respectively. The sub-categorization of Hodgkin lymphoma into classical form and non-classical form is the basis for clinicopathological approach of such type; whereas, Non-Hodgkin lymphoma is sub-grouped based on cell types into natural killer cell subtype, T-subtypes and B-subtype.
Aim of the study: Little is known about the phenotypic classes of lymphoid neoplasms common in Adiwaniyah Province, thus, the presents study was aiming at highlighting these types.
Materials and methods: Histopathological reports were retrieved from the archive of the central laboratories of Adiwaniyah teaching hospital for the last 4 years. The duration of search was limited to the period January the 1st 2019 to January the 1st 2023. Information about clinical presentation, age, gender, number of lymph nodes, size of lymph nodes, grade of the disease and immunohistochemical study were reported. There was no need for patients’ consent because the study was retrospective; however, ethical approval was issued by the ethical committee of the health directorate. Statistical description was based on reporting number, percentages, mean, range and standard deviation.
Results: The 4 cases of Hodgkin lymphoma were positive for CD15 and CD30 and negative for all other markers. All cases of Non-Hodgkin lymphoma were negative for CD15 and CD30 and positive for CD20 indicating that they are all of the B-subtype. Ten cases were positive for CD5, 8 cases were ё for CD45, 4 cases were positive for CD23, 4 cases were positive for CD79a, 2 cases were positive for CD3, 2 cases were positive for pancytokeratin and a single case was positive for cyclin D1.
Conclusion: Most of the cases of lymphoid neoplasms in Adiwaniyah province are of Non-Hodgkin lymphoma and they are mostly of B-cell type (CD20 positive); Hodgkin lymphoma accounted for small proportion and they all were positive for CD15 and CD30..
