Contribution of Biological Activity of Some Secondary Metabolites of Petroselinum Crispum (Mill.) Fuss, Against Bacteria Isolated From Patients' Urinary Tract Infections

Abstract

Due to their potential to generate a diverse array of physiologically active metabolites, medicinal plants play a significant role in the creation of novel pharmaceutical and medical products. They are being researched as possible targets for discovering new antibiotic compounds. Results from the agar well diffusion method demonstrated Petroselinum crispum's antibacterial efficacy against a few human pathogenic bacteria.

Four different plant extract concentrations were used: 25, 50, 75, and 100 mg/ml. The maximum inhibition zone for the ethanolic extract of P. crispum against P. mirabilis was 36.0 mm at a 25 mg/ml dose. In comparison, the minimum inhibition zone for P. aeruginosa measured 6.66 mm. At 100 mg/ml, the inhibition zone of P. crispum hexane extract was the largest (34.3 and 31.0 mm.) against P. mirabilis and E. coli, respectively. In contrast, Staphylococcus aureus had the lowest inhibition zone (5.00 mm). While harmful bacteria were suppressed to varying degrees at concentrations less than 100 mg/ml, several bacterial strains shown resistance to plant extracts at low doses. According to the results of the gas chromatography-mass spectrometry (GC-MS) examination, the chemical composition analysis of the Petroselinum crispum extract had a high concentration of organic components.