Systemic Lupus Erythematosus: A Narrative Review

Abstract

SLE, also known as erythematous systemic lupus, is autoimmune disorders can harm of many other organs, including the kidneys, skin, joints, and central nervous system. Which illness is often more likely to affect childbearing women and members of particular racial groups. Although impairments in complement caused by a unique, inherited single gene are significantly linked to "SLE", the majority of individuals have a polygenic inheritance of the condition. Environmental factors like, UV radiation exposure, Epstein-Barr virus infection, and hormonal factors incorporate with genetics to create of the disease, may result at the level of cytokines, T cells, B cells, and macrophages in immunological dysregulation. Although milder cases are more frequently recognized when they present themselves, nearly half of them worsen over time to more serious disease. About 70% of patients experience relapses and remissions. Lupus erythematosus (lupus) is systemic, among the most serious autoimmune conditions, is reviewed in detail in this paper. Discussions include symptoms, risk factors, genetics, and epidemiology. Long-term survival of patients, averting flare-ups and harm to organs, as well as improving quality of life in terms of health are all objectives of treatment. Organ-threatening conditions typically require a longer course of less rigorous medication to solidify the response and prevent relapses after a first round of intensive immunosuppressive treatment to reduce disease activity.