The Effect of Depakin Physiologically and Histology on the Kidney of Pregnant Female White Rats and the Investigation of the Protective Role of the Portulacea Oleracea Plant

Abstract

Aim: Knowledge of histological and physiological changes of the kidneys in female rats treated with lepipakine, and the possible protective role of the use of Portulacea Oleracea plant extract.

Materials and Methods: Female rats were divided into six groups (1) control group (2) treatment group with therapeutic dose (0.5mg/kg), depakine (3) double dose treatment group (1mg/kg) of depakine.(4) Portulacea Oleracea -aqueous extract group at 2mg/kg, (5) therapeutic dose of depakine (0.5mg/kg) with Portulacea Oleracea -aqueous extract (2mg/kg), (6) double dose of depakine (1mg/kg) with Portulacea Oleracea -aqueous extract (2mg/kg) Any day for 18 days, and the female rats were dissected on the 19th day of pregnancy, and the kidneys were taken for histological examination and blood was drawn from the heart for urea and creatinine tests.

Results: Laboratory examination of kidney function showed a significant difference P001, where high urea and creatine were observed in the two groups treated with depakine with different dose concentrations, and the aqueous extract of the Portulacea Oleracea plant showed its protective role in reducing creatine and urea levels as shown in the table(1-1). The histological examination showed that Depakin led to histological changes in the kidneys of the therapeutic and double dose group of the drug, which was represented by atrophy in the glomerulus, hemorrhage within the tissue area and the appearance of a plug in the tubules in addition to thickening in the vessel as shown in the picture (A, B, C). Compared to the control group . As for the plant extract, the Portulacea Oleracea contributed to reducing the negative effects of the drug as shown in the pictures (E, F, G).

Conclusion: The drug led to many histological and physiological changes in the kidneys, and the aqueous extract of the Portulacea Oleracea plant also contributed to improving the kidney injury caused by the drug by reducing urea and creatinine levels, and reducing renal histological damage.