Importance of Supramolecular Complexes of Glycyrrhizic Acid and Salts in Pharmaceuticals

Abstract

Currently, in the creation of effective drugs, it is important to increase the solubility of the drugs, their stability to the environment in which the drug is transported, oxidation processes, and to be able to control the release of the drug from the drug form. Molecular encapsulation technology of the main active drug substance is one of the modern methods for increasing the effectiveness of difficult-to-dissolve, highly toxic pharmacons. The essence of the technology is that the molecule of the drug is placed on the surface of the complex-forming substance molecule. This technology is applied to drugs that are poorly soluble in water, highly toxic, low in bioactivity, and used in high doses. Complex drugs have a number of advantages, showing high solubility and dissolution rate, high bio-reactivity, through which a rapid therapeutic effect is achieved, and a decrease in negative side effects is observed, they are protected from premature destruction under the influence of metabolic processes in the body, and the possibility of transport in the body is increased.