Assessment of the Effects of Ramipril and Pirindopril on Left Ventricle Systolic Function in Patients with Acute Myocardial Infarction without ST Segment Elevation

Abstract

This article analyzes the effect of ramipril and pyrindopril on the systolic function of the left ventricle in patients with acute myocardial infarction without ST segment elevation hospitalized in the ACS department of the Samarkand Regional Branch of the Republican Scientific and Practical Specialized Medical Center for Cardiology. The mean age of the patients was 55.7±3.4 years. All patients received standard AMI treatment ( statin, ASA, clopidogrel, beta-blocker, ACE inhibitor ) and were divided into 2 comparable groups depending on the therapy: in the 1st group (n=31), ramipril was used as an ACE in the initial dose of 5 mg 1 time per day, in the 2nd group (n=35) - pyrindopril at an initial dose of 2 mg 1 time per day with dose titration to the maximum tolerated. In a comparative assessment of the effectiveness of ACE inhibitors in patients in the early period of AMI, a more significant clinical efficacy and effect on postinfarction LV remodeling, a more significant effect on indicators of endothelial dysfunction and systemic inflammation with the use of ramipril were noted, which allows us to recommend it as the drug of choice in the treatment of patients with AMI, including to preserve the systolic function of the left ventricle.