Effect of the Combined Oral Contraceptive Pills (Yasmin) on the Fetal Malformation in Pregnant Mice (Mus Musculus)
Abstract
Background: Combined oral contraceptive pills (Yasmin) is an great contraceptive which used a very big vary of female worldwide , and it consists of synthetic estrogen (ethinyl estradiol) and a synthetic progesterone (drospirenone).
Aim of study:- This study was designed to inspect the effect of Yasmin on the deformation of fetus of pregnant mice when treated with the drug before pregnancy.
Methods:- In this study, 25 female mice were used, divided to three groups, the first group is control group (A) consisting of 5 pregnant mice, while the second group (B) and the third group (C) are the treatment group, each group consists of 10 pregnant mice which treated before pregnancy occurs with drug Yasmin for 10 days for group (B) and 20 days for group (C) at a dose (0.1ml) of concentration.
Results:- The results showed macroscopic congenital malformations in both treatment groups compared with control group (A), which include (exophthalmia, congestion in the brain, enlarged head size, pros encephalon, rough skin, micromelia, foot rotart, increased number of fingers, and Tail torsion), in addition to the presence of (bleeding at the end of the tail area) in third group. And the percentage of malformations in (group C) was higher than the (group B) . And observed that there was no extensive difference (P 0.05) in the rate of fetus weight, head, trunk and body length for the group (B), and there was extensive difference (P 0.05) in the group (C) contrast to the control group(A). And there was extensive difference in the length of the tail and hind limbs in both groups (B, C), and there was no extensive difference in average length of fore limbs of both groups (B, C), contrast to the control group(A).
Conclusion:- The results of the current study suggest the use of contraceptive pills (Yasmin) immediately before pregnancy occure has the potential to cause deformities in fetuses in the event of pregnancy occure.
